The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.
The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans. C3a receptor modulates immunity, arthritis, diet-induced obesity and cancers.
Agonists and antagonists
Potent and selective agonists and antagonists for C3aR have been discovered.
References
Further reading
External links
- "Anaphylatoxin Receptors: C3a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
- C3AR1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human C3AR1 genome location and C3AR1 gene details page in the UCSC Genome Browser.
